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Another anime that made use of the homunculus concept is
Cyberteam in Akihabara. The homunculi are the first line
of attack of Jun Goutokuji (in her guise of Blood
Falcon) when she confronts Hibari Hanakoganei in the
first episode.

A homunculus named Roger is a supporting character in
many of the Hellboy and B.P.R.D. comic books published
by Dark Horse.

Cyberteam in Akihabara
However, Roger is human-sized, which is
unusually large for a homunculus; other than the method
by which he was created, he seems to have more in common
with a golem.
Roger's size is commented upon at length
during B.P.R.D.: The Universal Machine, where Roger is
described as one of only two man-sized homunculi ever
created.
Homunculus - Serial Experiments Lain
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