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In the 1998 computer game Quest for Glory V: Dragon
Fire, Homonculi are winged monkey-esque creatures that
can be fought in the wilderness.

In the 1985 text-adventure game Brainscape!, by Lynne
Ostergren and W. Jeffrey Wilson, in which the player
must navigate his way out of his own brain, the
Homonculus is a mischievous imp that occasionally
interacts with the player.
In the video game GrimGrimoire, Homunculi can be
summoned as familiars as part of Alchemy magic.
In the Playstation 2 video game Shin Megami Tensei:
Persona 3, an item called "Homunculus" is used to shield
the main character from an instant death attack by
sacrificing itself in the main character's place.
In the roleplaying game Vampire: The Masquerade,
homunculi can be created by Tremere characters through
the use of a thaumaturgical ritual.
Homunculus - Unsorted uses of the term
"Homunculus"
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