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Far from his laboratory and hunted by the police as a
murderer, Hyde needed Lanyon’s help to get his potions
and become Jekyll again; when he undertook the
transformation in Lanyon’s presence, the shock of the
sight instigated Lanyon’s deterioration and death.
Meanwhile, Jekyll returned to his home, only to find
himself ever more helpless and trapped as the
transformations increased in frequency and necessitated
even larger doses of potion in order to reverse
themselves.

Jekyll - TV Series
It was the onset of one of these spontaneous
metamorphoses that caused Jekyll to slam his laboratory
window shut in the middle of his conversation with
Enfield and Utterson. Eventually, the potion began to
run out, and Jekyll was unable to find a necessary
ingredient to make more.
His ability to change back from
Hyde into Jekyll slowly vanished. Jekyll writes that
even as he composes his letter he knows that he will
soon become Hyde permanently, and he wonders if Hyde
will face execution for his crimes or choose to kill
himself. Jekyll notes that, in either case, the end of
his letter marks the end of the life of Dr. Jekyll. With
these words, both the document and the novel come to a
close.
Strange Case of Dr Jekyll and Mr Hyde -
Analysis
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